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Up-regulation of factors in membrane biogenesis and changes in the expression of cholesterol, chaperone, and FA desaturase genes induced by microsomal P450 overproduction in hepatocytes (27).
| Factors in membrane biogenesis | Expression of genes |
|---|---|
| XBP1 ↑ | Apo AI ↑ |
| NF-kB ↑ | LDLR ↑ |
| Apo B ↓ | |
| Chaperones ↑ | |
| FA desaturase ↑ |
