FIG. 6.

Effects of AAV1-P0-ICE nerve injection on pain behavior and motor function. Normal sciatic nerves in immune-competent (C57BL/6) mice were injected with AAV1-P0-GFP vector or AAV1-P0-ICE vector (1×10¹⁰ GC in 1 μl) or PBS two times over a 1-week period (4 and 10 days, arrows). Pain (von Frey method) and motor control (rotarod) were evaluated at 4-day intervals for 41 days. Results are represented as the mean±SEM of n=12 mice per group. Arrows indicate times of vector injection. *Significantly different from baseline for all groups (p≤0.001). Color images available online at www.liebertpub.com/hum