Table 1.
Propranolol and 4-OH-propranolol AUC 0→60min for time-course studies and/fold increase for significant changes vs. normal serum in rat hepatocytes. * p<0.05, n=4.
| Propranolol 1μM | Normal Serum | Hemodialysis Serum | Rifampin 10μM | Quinidine 30μM |
|---|---|---|---|---|
| AUC of Cumulative Drug (μM* min) | 410 ± 38 | 403 ± 87 | 421 ± 39 | *561 ± 18/1.37 |
| AUC of Intracellular Drug (μM* min) | 2.67 ± 1.14 | 3.48 ± 2.49 | 3.20 ± 0.46 | *6.51±0.44/2.44 |
| AUC of Cumulative Metabolite (μM* min) | 31.9 ± 17 | 40.3 ± 26.0 | 36.1 ± 24.0 | 31.0 ± 10.0 |
Results shown as average ± SD, /ratio compared to normal serum,
*
p<0.05 by ANOVA