. Author manuscript; available in PMC: 2013 Feb 25.

Published in final edited form as: J Pharm Sci. 2011 May 26;100(9):3831–3842. doi: 10.1002/jps.22640

Table 2.

Losartan and EXP3174 AUC 0→60_min for time-course studies and/fold increase or decrease for significant changes vs. normal serum in rat hepatocytes. n=4.

Losartan 1μM	Normal Serum	Hemodialysis Serum	Rifampin 10μM	Sulfaphenazole 1μM
AUC of Cumulative Drug (μM^* min)	32.1 ± 9.4	^*40.8 ± 6.2/1.27	^*53.0 ± 18.7/1.65	^*54.0 ± 19.8/1.68
AUC of Intracellular Drug (μM^* min)	44.6 ± 17.1	^*33.1 ± 20.4/0.74	^*23.7 ± 14.1/0.53	^*30.1 ± 20.9/0.67
AUC of Cumulative Metabolite (μM^* min)	1.47 ± 0.97	1.66±1.05	^*0.87 ± 0.47/0.59	^*1.09 ± 0.66/0.74

Results shown as average ± SD, /ratio compared to normal serum,

p<0.05 by ANOVA, n=3