Table I.
Receptor modulation, convulsant and hemagglutinating activities for the sponge extracts and fractions
| Sample | GluK2 |
Mouse | Hemagglutination | ||
|---|---|---|---|---|---|
| Conc. (μg/mL) | Mean % des. | τdes (ms) | |||
| Negative control | 99–100 | 4.5 | |||
| Crude extract | 50 | 48 | 59.1 | Convulsant | 3 |
| Ion exchange fractions | |||||
| 1 (4.5 mg) | 25 | 98 | 6.6 | Inactive | Inactive |
| 2 (6.7) | 25 | 100 | 4.0 | Inactive | Inactive |
| 3 (22.5) | 25 | 100 | 4.3 | Inactive | Inactive |
| 4 (34.1) | 50 | 100 | 4.2 | Inactive | Inactive |
| 5 (59.6) | 50 | 100 | 5.0 | Inactive | Inactive |
| 6 (105.4) | 50 | 99 | 6.5 | Inactive | 2 |
| 7 (85.8) | 50 | 57 | 55.3 | Inactive | 5 |
| 8 (91.2) | 50 | 38 | 51.5 | Inactive | 3 |
| 9 (57.4) | 50 | 73 | 33.1 | Inactive | 5 |
| 10 (13.0) | 50 | 46 | 43.7 | Inactive | 2 |
| 11 (1.5) | 50 | 97 | 8.1 | Convulsant | Inactive |
| 12 (2.4) | 50 | 84 | 12.8 | Convulsant | Inactive |
| Dialyzed fractions | |||||
| Inner solution | 25 | 69 | 55.6 | Inactive | 7 |
| Outer solution | 25 | 99 | 4.0 | Convulsant | – |