Table 1.
Summary of structural and functional properties of the lectin family receptors.
| Group | Molecules structure | Family members | Ligands | Expression | Function | Reference |
|---|---|---|---|---|---|---|
| MR | Mannose, fucose, and N-acetylglucosamine |
MoPh, retina DCs, LCs, Fbls, and kidney | Pathogen recognition, antigen presentation, clearance of endogenous cytopathic molecules, and regulation of circulating hormones | [3–14] | ||
| DC-SIGN | Mannose, ICAM-3 | Mesangial cells and CMs, MØ, and DCs | Pathogen recognition, antigen presentation, cell migration, and DC-T-cell interactions | |||
| C-type | Type-I Type-II (Tm) |
SIGNR-1 | Zymosan, mannans, and dextran | iDCs spleen MZ, lymph node, and pMØ | Clearance of blood borne antigens | |
| Dentin1 | β-glucans | DCs, neutrophils, and splenic T cells | Antifungal host defense, induction of TNF-α, and regulation of T-cell proliferation | |||
| Dectin2 | α-mannans | MØ, DCs | Impairment of UV-induced tolerance | |||
| mMGL1 | Gal | MØ, DCs | Internalization and antigen presentation, bind to CD45 to inhibit T cells | |||
| mMGL2 | Sructure Lex | MØ, DCs | Anti-inflammatory response | |||
| L-SIGN | Structure Le(a,b,y) | Liver sinusoidal endothelial cells | Antigen receptor | |||
|
| ||||||
| P-type | Type-I (Tm) |
CD-MPR CI-MPR |
Man-P-GlcNAc Man-6-P |
Lysosomal hydrolases | Transport Man-6-P containing acid hydrolases from the Golgi to endosomal/lysosomal compartments | [15–17] |
|
| ||||||
| F-type | AAA MsaFBP32 |
Fucose | Liver and kidney | Modulation of cell functions | [18–22] | |
|
| ||||||
| I-type | Type-I (Tm) |
Siglec-1 Siglec-2 Siglec-4 Siglec-15 |
Sialic acids with N- and O-linked glycosylations | Myeloid and lymphoid cells | Regulation of cell signaling from leucocytes | [23, 24] |
| Siglec-3 10 members humans (3, 5, 6, 7, 8, 9, 10, 11, 14, 16) Rodents Siglec-3, E, F, G, H |
Endocytic receptors | |||||
Abbreviations: Tm: transmenbrane; MØ: macrophages; pMØ: peritoneal macrophages; Dcs: dendritic cells; iDCs: immature dendritic cells; MoPh: mononuclear phagocytes; Fbls: fibroblasts; LCs: langerhans cells; CMs: cardiomyocytes; Lex: Lewis x, a, b, and y structures; Gal: galactose; MR: mannose receptor; DC-SIGN: dendritic cell-specific ICAM-3-grabbing nonintegrin; SIGNR-1: SIGN-related 1; homologe DC-SIGN; mMGL: macrophage galactose type c-lectin; L-SIGN: liver/lymph node-specific ICAM-3 grabbing nonintegrin; CD-MPR: cation-dependent mannose 6-phosphate receptor; CI-MPR: cation-independent mannose 6-phosphate receptor; Man-6-P: mannose 6-phosphate; Man-P-GlcNAc: mannose 6-phisphate N-acetylglucosamine ester; AAA: Anguilla anguilla agglutinin; MsaFBP32: F-lectin present in striped bass (Morone saxatilis).