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. 2013 Feb 14;62(3):905–911. doi: 10.2337/db12-0600

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Survival of islet grafts from IGRP_206–214-competent or IGRP_206–214-deficient donors in spontaneously diabetic IGRP_206–214-competent or IGRP_206–214-deficient NOD hosts. A: Individual blood glucose curves of diabetic NOD hosts receiving NOD.scid (n = 10) or NOD.rag2^KI/KI.IGRP_K209A/F213A^KI/KI islets (n = 9), and diabetic NOD.IGRP_K209A/F213A^KI/KI hosts receiving NOD.scid (n = 9) or NOD.rag2^−/−.IGRP_K209A/F213A^KI/KI islets (n = 5). B: Average onset of disease recurrence after transplantation (in days) in the four different donor/host combinations. P values were obtained by Mann-Whitney U test. C: Survival curves of grafts in diabetic NOD (left) or NOD.IGRP_K209A/F213A^KI/KI hosts (right). P values were calculated via log-rank test. For (B) and (C), differences between epitope-positive and epitope-negative grafts in epitope-positive hosts remained statistically significant upon exclusion of the epitope-negative graft that survived to 40 days (P = 0.0395 in B; and P = 0.0353 in C).