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. 2013 Feb 14;62(3):789–800. doi: 10.2337/db12-0365

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© 2013 by the American Diabetes Association.

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FIG. 6. — Consecutive IP forskolin injection in gcg-TCF7L2DN mice restored feeding-mediated repression of AMPK. A: Refeeding led to inhibited hypothalamic AMPK in the wild-type but not the T4 transgenic mice (top and middle panels), whereas consecutive IP forskolin injection restored this inhibitory effect of refeeding. Representative blots for three mice in each of the three groups. n = 6 for each of the three groups. B–D: Densitometry analyses of A. E: Forskolin treatment inhibited AMPK activity in the brain neuronal cell line mHypoE-20/2.