Table 2.
A summary of studies of surgically induced weight loss in obstructive sleep apnoea.
| Paper | Design | n | % Male | Group | Procedure | Followup months | ΔBMI | ΔAHI | % with OSA cure |
|---|---|---|---|---|---|---|---|---|---|
| Behrens et al., 2011 [65] | Retrospective, cohort | 34 (21 OSA) | 3 | BMI > 30 | LSG | 10 | 50.3→39.9 | ? | 76 |
| Martí-Valeri et al., 2007 [81] | Cohort | 30 (14 OSA) | 90 | Obese with associated respiratory comorbidity requiring NIPPV | RYGB | 12 | 56→32 | 64→17 (RDI) | ? |
| Fritscher et al., 2007 [78] | Cohort | 12 | 75 | BMI ≥ 35 with obesity-related comorbidity or ≥40 without and AHI ≥ 15 | RYGB | 18 | 56→34 | 46→16 | 25 |
| Haines et al., 2007 [69] | Prospective, cohort | 101 | ? | Obese, RDI > 5, ESS ≥ 6 | RYGB | 11 | 56→38 | 51→15 (RDI) | ? |
| Kalra et al., 2005 [66] | Retrospective, cohort | 34 (19 AHI ≥ 5) | ? | Adolescent, BMI ≥ 40, obesity-related comorbidity | RYGB | 5 | 60.8→41.6 | 9.1→0.6 | ? |
| Lankford et al., 2005 [70] | Retrospective, cohort | 15 | 40 | Obese, OSA | RYGB | 12 | 48→32 | 40→? | 0 |
| Guardiano et al., 2003 [71] | Retrospective, cohort | 8 | 12 | Obese, OSA | RYGB | 28 | 49→34 | 55→14 (RDI) | 50 |
| Peiser et al., 1984 [72] | Cohort | 15 | 93 | Morbidly obese with OSA | RYGB | 3 | ? | 82→15 | 80 |
| Lettieri et al., 2008 [73] | Retrospective, cohort | 24 | 25 | Obese with EDS, AHI ≥ 5 | GB | 12 | 51→32 | 48→24 | 4 |
| Rasheid et al., 2003 [74] | Prospective, cohort | 11 | ? | Obese, ESS ≥ 6, RDI > 5 | GB | 12 | 62→40 | 56→23 (RDI) | ? |
| Rao et al., 2009 [63] | Retrospective, cohort | 46 | ? | BMI ≥ 32.5 with obesity-related comorbidity or ≥37.5 without and AHI ≥ 15 | LAGB | 13 | 45→30 | 38→13 | 78 |
| Dixon et al., 2005 [75] | Prospective, cohort | 25 | 68 | BMI > 35, AHI > 25 | LAGB | 18 | 53→37 | 62→13 | ? |
| Busetto et al., 2005 [80] | Cohort | 17 | 100 | BMI > 50, AHI > 20 | IGB | 6 | 56→49 | 59→14 | 59 |
| Grunstein et al., 2007 [64] | Prospective, controlled, nonrandomised | 3023 | 30 | Female: BMI ≥ 38, male: BMI ≥ 34 | Various | 24 | 42→32 | ? | ? |
| Valencia-Flores et al., 2004 [67] | Prospective, cohort | 29 | 45 | Morbidly obese | Various | 14 | 56→39 | 52→? | 46 |
| Poitou et al., 2006 [79] | Prospective cohort | 35 | 17 | BMI > 40, AHI > 10 | RYGB, LAGB | 12 | 51→40 | 24→10 | 63 |
| Pillar et al., 1994 [76] | Cohort | 14 | 79 | Morbidly obese with OSA | RYGB, VBG | 4 | 45→33 | 40→11 | 43 |
| Charuzi et al., 1992 [77] | Cohort | 47 | ? | Morbidly obese with OSA | RYGB, VBG | 10 | ? | 61→8 | 40 |
| Omana et al., 2010 [68] | Retrospective, cohorts | 123 | 24 | Obese | LSG (49) v LAGB (74) |
15 17 |
52→? 44→? |
? ? |
55 25 |
Abbreviations: ΔAHI: apnoea hypopnoea index before and after intervention, ΔBMI: body mass index before and after intervention, EDS: excessive daytime somnolence, ESS: epworth sleepiness scale, GB: gastric bypass, IGB: intragastric balloon, LAGB: laparoscopic adjustable gastric banding, LSG: laparoscopic sleeve gastrectomy, n number, NIPPV: noninvasive positive pressure ventilation, OSA: obstructive sleep apnoea, RDI: respiratory disturbance index, RYGB: roux-en-Y gastric bypass, VBG: vertical banded.