Table 3.
Correlation of HBR motifs and characteristic functions of hRNase3.
| Location | Function | |||||
|---|---|---|---|---|---|---|
| RNase | Cytotoxicity | Cell binding activity | HS binding activity | Endocytic activity | Lipid binding activity | |
| RNase3 | O | O | O | O | O | O |
| HBR1-mt RNase3 | No activity | Decrease 50% | Increase 50% | Decrease 40% | No activity | |
| HBR2-mt RNase3 | Similar | Similar | Decrease 20% | Similar | Decrease 50% | |
| HBR3-mt RNase3 | Decrease 30% | No activity | Decrease 20% | Similar | Similar | |
| HBPRNase3(32–41) | X | X | O | O | ND | O |
Note: O, X, and ND, respectively, represent active, inactive, and not determined.