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PM10-induced IL-1β release dependent on caspase-1 activation in THP-1-derived macrophages cells. The cells were pretreated with the caspase-1 inhibitor, z-YVAD-fmk (10 μM) for 1 h, and exposed to summer PM10 for 6 h. Results are the mean and s.d. of three independent experiments. CTRL: untreated cells. ***P < 0.001 versus CTRL, ### P < 0.001 versus summer PM10.
