Table 2.
Association of the APOA5 −1131T>C polymorphism with MS parameters in the study population.
| Variables | TT/TC/CC | Slope (95% CI) | P value | |
|---|---|---|---|---|
| Total (2901) |
Number (%) | 1404 (48.40)/1237 (42.64)/260 (8.96) | — | — |
| Age (years) | 47.93 ± 15.54/47.33 ± 15.53/48.92 ± 14.61 | — | — | |
| SBP (mm Hg) | 119.67 ± 15.77/119.69 ± 15.58/122.27 ± 15.33 | 0.589 (−0.244, 1.422) | 0.166 | |
| DBP (mm Hg) | 76.88 ± 11.37/76.99 ± 11.13/78.20 ± 10.10 | 0.326 (−0.282, 0.934) | 0.264 | |
| WC (cm) | 83.94 ± 9.72/83.65 ± 9.81/84.97 ± 9.73 | 0.051 (−0.451, 0.553) | 0.843 | |
| FBG (mg/dL) | 99.02 ± 27.91/98.98 ± 26.24/99.61 ± 30.27 | −0.013 (−1.505, 1.479) | 0.987 | |
| LogTG (mg/dL) | 2.00 ± 0.23/2.04 ± 0.24/2.13 ± 0.24 | 0.056 (0.044, 0.069) | 2.286E − 19 | |
| HDL-C (mg/dL) | 48.34 ± 12.84/46.69 ± 12.43/44.16 ± 10.97 | −1.700 (−2.368, −1.031) | 6.550E − 07 | |
|
| ||||
| MS (1004) |
Number (%) | 452 (15.58)/429 (14.79)/123 (4.24) | — | — |
| Age (years) | 55.89 ± 13.95/54.92 ± 13.68/55.71 ± 12.48 | — | — | |
| SBP (mm Hg) | 129.38 ± 16.09/127.77 ± 15.48/131.40 ± 13.39 | 0.185 (−1.218, 1.587) | 0.796 | |
| DBP (mm Hg) | 82.73 ± 11.38/82.40 ± 11.23/83.30 ± 9.33 | 0.065 (−0.941, 1.071) | 0.899 | |
| WC (cm) | 91.17 ± 7.51/90.57 ± 8.00/90.92 ± 7.56 | −0.328 (−1.018, 0.362) | 0.351 | |
| FBG (mg/dL) | 112.38 ± 37.56/111.68 ± 34.69/109.70 ± 39.73 | 1.103 (−4.389, 2.182) | 0.510 | |
| LogTG (mg/dL) | 2.17 ± 0.20/2.22 ± 0.22/2.27 ± 0.24 | 0.046 (0.028, 0.065) | 1.457E − 06 | |
| HDL-C (mg/dL) | 40.62 ± 8.94/39.05 ± 8.45/39.28 ± 7.62 | −0.818 (−1.566, −0.071) | 0.032 | |
|
| ||||
| Control (1897) |
Number (%) | 952 (32.82)/808 (27.85)/137 (4.72) | — | — |
| Age (years) | 44.15 ± 14.81/43.30 ± 14.94/42.82 ± 13.69 | — | — | |
| SBP (mm Hg) | 115.06 ± 13.35/115.39 ± 13.84/114.07 ± 11.98 | −0.223 (−1.15, 0.704) | 0.637 | |
| DBP (mm Hg) | 74.10 ± 10.26/74.12 ± 9.95/73.63 ± 8.47 | −0.205 (−0.907, 0.497) | 0.566 | |
| WC (cm) | 80.50 ± 8.71/79.97 ± 8.64/79.63 ± 8.26 | −0.519 (−1.098, 0.06) | 0.079 | |
| FBG (mg/dL) | 92.67 ± 18.83/92.24 ± 16.87/90.55 ± 12.42 | −0.822 (−2.067, 0.424) | 0.196 | |
| LogTG (mg/dL) | 1.92 ± 0.19/1.95 ± 0.19/2.02 ± 0.18 | 0.042 (0.029, 0.055) | 2.158E − 10 | |
| HDL-C (mg/dL) | 52.01 ± 12.78/50.75 ± 12.30/48.55 ± 11.67 | −1.304 (−2.174, −0.435) | 0.003 | |
Values are indicated as the mean ± standard deviation.
P value: multiple regression analysis adjusted for age and sex (TT, TC, CC).
Abbreviations: CI: confidence interval; SBP: systolic blood pressure; DBP: diastolic blood pressure; WC: waist circumference; FBG: fasting blood glucose; LogTG: log-transformed triglyceride; HDL-C: high-density lipoprotein cholesterol.
Bold indicates statistical significance (P < 0.05).