Table 3.
Chr | SNP | Region | Gene | Alleles | European
|
RAF2
|
OR (95%CI)3 | P | |||
---|---|---|---|---|---|---|---|---|---|---|---|
R1 | OR1 | RAF2 | Case | Control | |||||||
2 | rs1465618 | 2p21 | THADA | A>G | A | 1.15 | 0.212 | 0.745 | 0.716 | 1.16(1.02, 1.31) | 0.020 |
2 | rs721048 | 2p15 | EHBP1 | G>A | A | 1.18 | 0.137 | 0.042 | 0.031 | 1.36(1.01, 1.83) | 0.042 |
2 | rs12621278 | 2q31 | ITGA6 | A>G | A | 1.35 | 0.960 | 0.740 | 0.710 | 1.16(1.03, 1.31) | 0.019 |
3 | rs2660753 | 3p12 | C>T | T | 1.24 | 0.102 | 0.312 | 0.295 | 1.08(0.96, 1.22) | 0.212 | |
3 | rs10934853 | 3q21 | C>A | A | 1.12 | 0.239 | 0.447 | 0.430 | 1.07(0.96, 1.20) | 0.236 | |
4 | rs17021918 | 4q22 | PDLIM5 | C>T | C | 1.14 | 0.646 | 0.649 | 0.652 | 0.99(0.88, 1.11) | 0.815 |
4 | rs7679673 | 4q24 | TET2 | A>C | C | 1.14 | 0.624 | 0.221 | 0.192 | 1.20(1.05, 1.37) | 9.39E-03 |
6 | rs9364554 | 6q25 | SLC22A3 | C>T | T | 1.17 | 0.274 | 0.315 | 0.329 | 0.94(0.83, 1.06) | 0.282 |
7 | rs10486567 | 7p15 | JAZF1 | T>C | C | 1.16 | 0.752 | 0.159 | 0.141 | 1.15(0.98, 1.34) | 0.081 |
7 | rs6465657 | 7q21 | LMTK2 | C>T | C | 1.14 | 0.509 | 0.872 | 0.857 | 1.13(0.96, 1.33) | 0.134 |
8 | rs2928679 | 8p21 | NKX3.1 | G>A | A | 1.13 | 0.456 | 0.138 | 0.132 | 1.05(0.90, 1.24) | 0.522 |
8 | rs1512268 | 8p21 | NKX3.1 | G>A | A | 1.17 | 0.420 | 0.314 | 0.272 | 1.23(1.09, 1.38) | 9.39E-04 |
8 | rs10086908 | 8q24 (Region 5) | T>C | T | 1.13 | 0.625 | 0.844 | 0.808 | 1.28(1.11, 1.48) | 9.24E-04 | |
8 | rs16901979 | 8q24 (Region 2) | C>A | A | 1.82 | 0.031 | 0.322 | 0.248 | 1.44(1.28, 1.63) | 5.14E-09 | |
8 | rs16902094 | 8q24.21 | A>G | G | 1.20 | 0.271 | 0.273 | 0.279 | 0.97(0.85, 1.10) | 0.595 | |
8 | rs620861 | 8q24 (Region 4) | G>A | G | 1.16 | 0.619 | 0.572 | 0.567 | 1.02(0.91, 1.14) | 0.717 | |
8 | rs6983267 | 8q24 (Region 3) | T>G | G | 1.20 | 0.487 | 0.454 | 0.434 | 1.09(0.97, 1.21) | 0.150 | |
8 | rs1447295 | 8q24 (Region 1) | C>A | A | 1.47 | 0.071 | 0.209 | 0.160 | 1.38(1.20, 1.60) | 7.04E-06 | |
9 | rs1571801 | 9q33 | DAB2IP | G>T | T | 1.17 | 0.290 | 0.050 | 0.051 | 0.98(0.76, 1.27) | 0.893 |
10 | rs10993994 | 10q11 | MSMB | T>C | T | 1.25 | 0.341 | 0.519 | 0.490 | 1.12(1.01, 1.26) | 0.038 |
10 | rs4962416 | 10q26 | CTBP2 | A>G | G | 1.15 | 0.257 | 0.011 | 0.009 | 1.20(0.69, 2.08) | 0.521 |
11 | rs7127900 | 11p15 | IGF2/IGF2AS | G>A | A | 1.25 | 0.235 | 0.104 | 0.102 | 1.03(0.86, 1.24) | 0.752 |
11 | rs12418451 | 11q13 | G>A | A | 1.16 | 0.342 | 0.064 | 0.065 | 0.99(0.79, 1.24) | 0.926 | |
11 | rs10896449 4 | 11q13 | A>G | G | 1.16 | 0.532 | 0.111 | 0.086 | 1.31(0.82–2.10) | 0.261 | |
17 | rs11649743 | 17q12 | HNF1B | C>T | C | 1.16 | 0.757 | 0.692 | 0.657 | 1.17(1.04, 1.32) | 8.51E-03 |
17 | rs4430796 | 17q12 | HNF1B | T>C | T | 1.22 | 0.491 | 0.734 | 0.713 | 1.11(0.98, 1.26) | 0.088 |
17 | rs1859962 | 17q24 | T>G | G | 1.21 | 0.527 | 0.426 | 0.425 | 1.01(0.9, 1.12) | 0.934 | |
19 | rs8102476 | 19q13 | A>G | G | 1.12 | 0.504 | 0.369 | 0.374 | 0.98(0.87, 1.10) | 0.721 | |
19 | rs887391 | 19q13 | T>C | T | 1.14 | 0.757 | 0.618 | 0.592 | 1.12(1.00, 1.25) | 0.056 | |
19 | rs2735839 | 19q13 | KLK2/KLK3 | G>A | G | 1.30 | 0.863 | 0.604 | 0.612 | 0.97(0.87, 1.09) | 0.581 |
22 | rs9623117 | 22q13 | TNRC6B | T>C | C | 1.13 | 0.221 | 0.034 | 0.037 | 0.94(0.70, 1.27) | 0.681 |
22 | rs5759167 | 22q13 | TTLL1/BIK | G>T | G | 1.18 | 0.549 | 0.730 | 0.694 | 1.19(1.06, 1.35) | 4.81E-03 |
X | rs5945619 | Xp11 | NUDT10/NUDT11 | A>G | G | 1.27 | 0.385 | 0.084 | 0.068 | 1.25(0.94, 1.68) | 0.130 |
Risk allele (RA) reported in Europeans. The ORs were derived from pooled results in populations of European descent;20
Risk allele frequency (RAF) reported in HapMap or from the results in our population;
Allelic odds ratio (OR) and 95% confidence interval (95% CI);
The results for rs10896449 were available only from set 1, and did not include set 2 due to a low call rate for set 2.