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. Author manuscript; available in PMC: 2013 Feb 25.
Published in final edited form as: Cancer Sci. 2011 Aug 10;102(10):1916–1920. doi: 10.1111/j.1349-7006.2011.02036.x

Table 3.

PCa susceptibility loci identified in populations of European descent and their associations with PCa risk in Chinese men

Chr SNP Region Gene Alleles European
RAF2
OR (95%CI)3 P
R1 OR1 RAF2 Case Control
2 rs1465618 2p21 THADA A>G A 1.15 0.212 0.745 0.716 1.16(1.02, 1.31) 0.020
2 rs721048 2p15 EHBP1 G>A A 1.18 0.137 0.042 0.031 1.36(1.01, 1.83) 0.042
2 rs12621278 2q31 ITGA6 A>G A 1.35 0.960 0.740 0.710 1.16(1.03, 1.31) 0.019
3 rs2660753 3p12 C>T T 1.24 0.102 0.312 0.295 1.08(0.96, 1.22) 0.212
3 rs10934853 3q21 C>A A 1.12 0.239 0.447 0.430 1.07(0.96, 1.20) 0.236
4 rs17021918 4q22 PDLIM5 C>T C 1.14 0.646 0.649 0.652 0.99(0.88, 1.11) 0.815
4 rs7679673 4q24 TET2 A>C C 1.14 0.624 0.221 0.192 1.20(1.05, 1.37) 9.39E-03
6 rs9364554 6q25 SLC22A3 C>T T 1.17 0.274 0.315 0.329 0.94(0.83, 1.06) 0.282
7 rs10486567 7p15 JAZF1 T>C C 1.16 0.752 0.159 0.141 1.15(0.98, 1.34) 0.081
7 rs6465657 7q21 LMTK2 C>T C 1.14 0.509 0.872 0.857 1.13(0.96, 1.33) 0.134
8 rs2928679 8p21 NKX3.1 G>A A 1.13 0.456 0.138 0.132 1.05(0.90, 1.24) 0.522
8 rs1512268 8p21 NKX3.1 G>A A 1.17 0.420 0.314 0.272 1.23(1.09, 1.38) 9.39E-04
8 rs10086908 8q24 (Region 5) T>C T 1.13 0.625 0.844 0.808 1.28(1.11, 1.48) 9.24E-04
8 rs16901979 8q24 (Region 2) C>A A 1.82 0.031 0.322 0.248 1.44(1.28, 1.63) 5.14E-09
8 rs16902094 8q24.21 A>G G 1.20 0.271 0.273 0.279 0.97(0.85, 1.10) 0.595
8 rs620861 8q24 (Region 4) G>A G 1.16 0.619 0.572 0.567 1.02(0.91, 1.14) 0.717
8 rs6983267 8q24 (Region 3) T>G G 1.20 0.487 0.454 0.434 1.09(0.97, 1.21) 0.150
8 rs1447295 8q24 (Region 1) C>A A 1.47 0.071 0.209 0.160 1.38(1.20, 1.60) 7.04E-06
9 rs1571801 9q33 DAB2IP G>T T 1.17 0.290 0.050 0.051 0.98(0.76, 1.27) 0.893
10 rs10993994 10q11 MSMB T>C T 1.25 0.341 0.519 0.490 1.12(1.01, 1.26) 0.038
10 rs4962416 10q26 CTBP2 A>G G 1.15 0.257 0.011 0.009 1.20(0.69, 2.08) 0.521
11 rs7127900 11p15 IGF2/IGF2AS G>A A 1.25 0.235 0.104 0.102 1.03(0.86, 1.24) 0.752
11 rs12418451 11q13 G>A A 1.16 0.342 0.064 0.065 0.99(0.79, 1.24) 0.926
11 rs10896449 4 11q13 A>G G 1.16 0.532 0.111 0.086 1.31(0.82–2.10) 0.261
17 rs11649743 17q12 HNF1B C>T C 1.16 0.757 0.692 0.657 1.17(1.04, 1.32) 8.51E-03
17 rs4430796 17q12 HNF1B T>C T 1.22 0.491 0.734 0.713 1.11(0.98, 1.26) 0.088
17 rs1859962 17q24 T>G G 1.21 0.527 0.426 0.425 1.01(0.9, 1.12) 0.934
19 rs8102476 19q13 A>G G 1.12 0.504 0.369 0.374 0.98(0.87, 1.10) 0.721
19 rs887391 19q13 T>C T 1.14 0.757 0.618 0.592 1.12(1.00, 1.25) 0.056
19 rs2735839 19q13 KLK2/KLK3 G>A G 1.30 0.863 0.604 0.612 0.97(0.87, 1.09) 0.581
22 rs9623117 22q13 TNRC6B T>C C 1.13 0.221 0.034 0.037 0.94(0.70, 1.27) 0.681
22 rs5759167 22q13 TTLL1/BIK G>T G 1.18 0.549 0.730 0.694 1.19(1.06, 1.35) 4.81E-03
X rs5945619 Xp11 NUDT10/NUDT11 A>G G 1.27 0.385 0.084 0.068 1.25(0.94, 1.68) 0.130
1

Risk allele (RA) reported in Europeans. The ORs were derived from pooled results in populations of European descent;20

2

Risk allele frequency (RAF) reported in HapMap or from the results in our population;

3

Allelic odds ratio (OR) and 95% confidence interval (95% CI);

4

The results for rs10896449 were available only from set 1, and did not include set 2 due to a low call rate for set 2.