Table 1.
Results of functional classification clustering analysis performed in DAVID (http://david.abcc.ncifcrf.gov) on the genes that were upregulated (n = 93) by insulin
| Gene Functional Classification | Gene Name | Gene Symbol |
|---|---|---|
| Transcription binding, activity and regulation (n = 18) | nuclear receptor subfamily 4, group a, member 3 | NR4A3 |
| kruppel-like factor 10 | KLF10 | |
| v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) | MAFF | |
| v-ets erythroblastosis virus e26 oncogene homolog 2 (avian) | ETS2 | |
| nuclear factor, interleukin 3 regulated | NFIL3 | |
| jun b proto-oncogene | JUNB | |
| interferon, gamma-inducible protein 16 | IFI16 | |
| v-myc myelocytomatosis viral oncogene homolog (avian) | MYC | |
| activating transcription factor 3 | ATF3 | |
| btg family, member 2 | BTG2 | |
| fbj murine osteosarcoma viral oncogene homolog b | FOSB | |
| early growth response 1 | EGR1 | |
| v-fos fbj murine osteosarcoma viral oncogene homolog | FOS | |
| basic helix-loop-helix domain containing, class b, 2 | BHLHB2 | |
| tgfb-induced factor (tale family homeobox) | TGIF | |
| hairy and enhancer of split 1, (drosophila) | HES1 | |
| tsc22 domain family, member 2 | TSC22D2 | |
| ccaat/enhancer-binding protein (c/ebp), delta | CEBPD | |
| Protein kinase activity (n = 4) | pim-1 oncogene | PIM1 |
| snf1-like kinase | SNF1LK | |
| serum/glucocorticoid-regulated kinase | SGK | |
| tribbles homolog 1 | TRIB1 | |
| Inflammation and chemokine activity (n = 4) | chemokine (C-C motif) ligand 2 | CCL2 |
| chemokine (C-C motif) ligand 8 | CCL8 | |
| chemokine (C-X-C motif) ligand 2 | CXCL2 | |
| interleukin 1 receptor, type I | IL1R1 | |
| Metal ion binding (n = 6) | metallothionein 2e | MT2A |
| metallothionein 1f | MT1F | |
| metallothionein 1e | MT1E | |
| metallothionein 1h | MT1H | |
| metallothionein 1m | MT1M | |
| metallothionein 1x | MT1X |