Table 2.

Orbitofrontal cortex gray matter volumes in bipolar disorder patients and healthy subjects

Gray matter volumes (cm3) (Mean ± S.D.)
	Males		F	p*
	Patients (n = 6)	Controls (n = 11)
Region
Total OFC	18.35 ± 4.09	19.76 ± 3.14	1.44	0.24
Right	9.48 ± 2.62	10.46 ± 1.82	2.1	0.16
Left	8.99 ± 1.65	9.44 ± 1.73	0.56	0.46
Mediala	6.62 ± 2.03	7.97 ± 0.78	4.46	0.04
Right medial	3.43 ± 1.14	4.17 ± 0.47	4.79	0.04
Left medial	3.65 ± 0.98	3.89 ± 0.42	0.55	0.46
Lateralb	5.41 ± 0.54	6.46 ± 1.52	2.89	0.10
Right lateral	2.79 ± 0.55	3.42 ± 0.54	5.11	0.03
Left lateral	2.62 ± 0.43	3.04 ± 1.05	0.99	0.33
	Females
	Patients (n = 8)	Controls (n = 9)
Region
Total OFC	18.35 ± 3.36	14.18 ± 4.33	2.84	0.10
Right	9.70 ± 2.01	7.76 ± 2.66	1.14	0.30
Left	8.82 ± 1.47	6.54 ± 1.81	5.22	0.03
Mediala	7.73 ± 1.55	6.13 ± 1.56	3.13	0.09
Right medial	4.18 ± 0.81	3.32 ± 0.90	2.5	0.13
Left medial	3.56 ± 0.78	2.82 ± 0.72	3.45	0.07
Lateralb	6.3 ± 1.38	4.33 ± 1.24	7.2	0.01
Right lateral	3.16 ± 0.69	2.4 ± 0.75	3.45	0.07
Left lateral	3.13 ± 0.79	1.92 ± 0.53	8.51	0.007

^*The p-values shown are uncorrected for multiple comparisons. Only the difference for left lateral OFC volume in females is significant at the p < 0.05 level after Bonferroni correction. All F-tests were based on 1 and 28 degrees of freedom.

^aMedial = right medial + left medial.

^bLateral = right lateral + left lateral.