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Neural progenitor specification is initiated in Yy1 cKO embryos. WISH of Sox2 (A, B, F, G), Otx2 (C, D, H, I) and Oct4 (E, J) in WT (A–E) and mutant embryos (F–J) at E7.0 (A, C, F, H) and E7.5 (B, D, E, G, I, J). Anterior Sox2 and Oct4 expressing cells demonstrate specification of neural progenitors, despite the drastic reduction in Otx2 expression.
