Figure 4.

Examples of the localization of Prussian blue-positive deposits in relation to endothelial and subendothelial cells in an advanced lesion of a WHHL rabbit 1 hour after VSOP injection (A) in comparison with anti-RAM-11 stain (B). Iron deposits in the medial layer of an atherosclerotic vessel wall in a WHHL rabbit 24 hours after VSOP injection (C). There was no difference between 1 hour and 24 hours after injection with regard to these patterns.

Abbreviations: WHHL, Watanabe heritable hyperlipidemic; VSOP, very small superparamagnetic iron oxide particles.