Table S1.

Definition of AHA lesion types according to Stary et al¹

AHA lesion type	Definition
1	Initial lesion, single subendothelial foam cells, focal subendothelial GAG accumulation
2	Fatty streak, foci of subendothelial foamy macrophages, beginning confluent GAG accumulation
3	Preatheroma, diffuse intimal thickening consisting of smooth muscle cells in GAG-rich matrix without necrosis or confluent extrcellular lipid
4	Monolayered intimal atheroma, confluent GAG and lipid core, calcium score 0–2, thin cap, low collagen content
5A	Multilayered intimal atheroma, multiple layers of confluent GAG and lipid core, calcium score 0–2, thin cap, low collagen content
5B	Multilayered intimal atheroma, multiple layers of confluent GAG and lipid core, calcium score 3, thin cap, low collagen content
5C	Multilayered fibrotic lesion, collagen-rich lesion with minor lipid or GAG pools, calcium score 0–3
6	Erosion, hemorrhage, endothelial surface thrombosis

Abbreviations: AHA, American Heart Association; GAG, glycosaminoglycan.

Note: Copyright © 2000, Walter Kluwer Health. Adapted with permission from Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262–1275.²