pH dependence of yields of fluorescence from hairpin peptides with Trp in position 1 and various ionizable residues replacing either Ala8 or Phe10. A: Ala8/Phe10 (●), Asp8/Phe10 (○), Glu8/Phe10 (Δ). B: Ala8/Phe10 (●), His8/Phe10 (○), Ala8/His10 (Δ). C: Ala8/Phe10 (●), Orn8/Phe10 (○), Cys8/Phe10 (Δ). D: Ala8/Phe10 (●), Tyr8/Phe10 (○), Ala8/Tyr10 (Δ).