Table 1.

Folding of Hairpin Peptides at 280 K. ^a

Substitutions	pH	% Foldedb
none	6.5	91.0
Ala8/ε-N-acetyl-Lys 8	6.5	93.6
Ala8Asn	6.5	92.4
Ala8Asp	6.5	88.0
	2.5	89.4
Ala8Lys	6.5	91.5
Ala8Cha c	6.5	98.5
Ala8Gln	6.5	92.0
Ala8Glu	6.5	89.1
Ala8Ser	6.5	94.5
Ala8Cys 8	6.0	84.5
	10.5	48.9
Ala8Orn c	6.5	92.1
Ala8Tyr	6.0	91.7
	10.67	90.7
Ala8His	7.85	97.7
	2.5	94.9
Phe10Tyr	6.5	90.4
	10.7	99.0
Phe10His	7.85	66.6
	2.5	65.9
Phe10Leu	6.5	59.1
Trp1N-Ac-Phe / Phe10Trp	6.5	41.1

^aThe peptides are Ac-WVTIpGKAIFTG-NH₂ with the indicated substitutions for residues in bold font. Except where indicated (last row), all the peptides had Trp at position 1.

^bChemical-shift deviations of the following atoms were used to calculate the % folding: Val2 NH, Ile3 Hα, Ile4 NH, X8 Hα, Ile9 NH, and when X = Phe or Tyr, X10 Hβ3 and X10 Hδ.

^cAbbreviations: Cha = cyclohexylalanine, Orn = ornithine.