FIGURE 3.

BCR-mediated Ca²⁺ mobilization is mainly p110δ-dependent. A, kinetics of calcium mobilization was monitored using ratiometric measurement of Fluo-3 and Fura Red fluorescence. FO B cell population was distinguished by flow cytometry (CD24 and CD1d). Data are representative of three independent experiments. B, the peak Ca²⁺ response after anti-IgM-mediated BCR cross-linking was plotted for three independent experiments (**, p < 0.005; ***, p < 0.001, repeated-measures analysis of variance, measured versus the untreated control).