TABLE 1.

IC₅₀ values for inhibition of class I PI3K isoforms and mammalian target of rapamycin (mTOR)

Compound	IC50
	PI3K class I				mTOR	Refs.
	p110α	p110β	p110γ	p110δ
	nm				nm
A66	32	>12,500	3,450	>1,250	>5000	9
MLN1117	15	4,500	1,900	13,900	1,670
TGX-221	5,000	5	>10,000	100	NDa	26
MLN1316	10	8	780	2,200	2,100
IC87114	>10,000	1,820	1,240	70	ND	27
GDC-0941	3	33	75	3	580	28
ZSTK474	16	44	49	4.6	>10,000	29

^a ND, not determined.