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. 2013 Jan 2;288(8):5606–5615. doi: 10.1074/jbc.M112.422964

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Intracellular distribution of ECE-2. SH-SY5Y-APP cells transiently transfected with ECE-2 (variant 2) were co-stained with antibodies against ECE-2 and markers of various intracellular compartments. Co-localization of ECE-2 with rab5, rab7, and lamp-1, markers of early endosome, late endosome, and lysosome, respectively, demonstrated that ECE-2 is mostly located in the endosomal/lysosomal pathway. In contrast, ECE-2 did not co-localize with TGN38, a marker of the trans-Golgi network, suggesting that ECE-2 does not conduct its activity within the secretory pathway.