FIGURE 4.

Comparison of mutation rates between Pol δ^A692Q and Pol δ^D400A. Mutation rates for individual base substitutions from the gapped filling assay using purified Pol δ^A692A (black bars, values on left axis) are compared with published values (10) for Pol δ^D400A (gray bars, values on right axis). Pol δ^A692Q displays an elevated base substitution rate overall, relative to Pol δ^D400A, with the largest increase in mutagenesis by the A692Q variant occurring in the setting of G→A and C→A substitutions.