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. 2013 Feb 25;8(2):e57263. doi: 10.1371/journal.pone.0057263

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© 2013 Coulstock et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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– In vivo imaging of mIFNα2 and mIFNα2-DOM26h-196-61. Localisation of ¹¹¹In labelled mIFNα2 in beige SCID mouse and ¹¹¹In labelled mIFNα2-DOM26h-196-61 in BALB/c mouse at 3, 24 and 72 hours post injection. Images were obtained following intravenous administration of 12–15 MBq of radiolabeled compound via tail vein injection in BALB/c mice. Images show that signal is observed in liver, kidney and bladder with IFN molecules. B– In vivo imaging of mIFNα2-V_HD2 and mIFNα2-DOM26h-196-61. Localisation of ¹¹¹In labelled mIFNα2-dAb fusions in BALB/c mice at 3, 24 and 72 hours post injection. Images were obtained following intravenous administration of 12–15 MBq of radiolabelled compound via tail vein injection in BALB/c mice. Images show that signal is observed in liver, kidney and bladder with both fusion proteins; however the extent of liver uptake is clearly higher in the animal injected with mIFNα2-DOM26h-196-61, in agreement with biodistribution data.