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. 2013 Feb 25;8(2):e57591. doi: 10.1371/journal.pone.0057591

Figure 2. Disease symptoms in hSCARB2-Tg mice infected with the B genotype of EV71.

Figure 2

(A) 1-d-old hSCARB2-Tg mice were injected s.c. with 1×107 pfu of E59 (B4) or the N-2838 (B5) strain. As a negative control, 1-d-old hSCARB2-Tg mice were injected with s.c. with a VP-SFM medium, including non-Tg mice infected with 1×107 pfu of E59 or N-2838. The mice were monitored daily to (B) score the HFMD-like syndrome and (C) the CNS-like hind limb paralysis, followed the criteria described in the Materials and Methods section. Data are representative of the mean scores obtained from the individual number of (N) mice per group. One-way anova with Kruskal-Wallis test was used for statistical analysis and the error bar of each group was included. Significant difference of Tg mice infected with N-2838 vs. E59 was shown as *: p<0.05, **: p<0.01, and ***: p<0.001, the Tg mice vs. non-Tg infected with E59 was shown as †: p<0.05 and ††: p<0.01, and the Tg mice vs. non-Tg infected with N-2838 was shown as #: p<0.05 and ##: p<0.01.