Table 2. NucPred Analysis of the 22 Members of GPCR Family C.

Name	8th helix	NLS in 8th helix	NLS elsewhere	NucPred Score
mGlu1	+	+	+	0.46
mGlu2	−	−	+	0.08
mGlu3	+	−	+	0.11
mGlu4	+	+	−	0.55
mGlu5	+	−	−	0.45
mGlu6	+	+	−	0.36
mGlu7	+	+	−	0.58
mGlu8	+	+	−	0.48
GPRC6A	+	−	−	0.3
CaR	+	−	+	0.61
T1R1	+	−	−	0.06
T1R2	−	−	−	0.21
T1R3	+	−	+	0.15
GABAB2	−	−	+	0.43
GABAB1	+	+	+	0.33
GPR156	+	−	+	0.78
GPR158	+	+	+	0.96
GPR179	+	+	+	0.85
GPRC5D	−	−	−	0.09
GPRC5A	−	−	+	0.11
GPRC5B	−	−	+	0.02
GPRC5C	−	−	+	0.21

The PSIPRED program [20] predicted the presence of 8^th helix and the NucPred score represents the threshold score for the fraction of proteins, correctly predicted as nuclear (specificity) versus the fraction of true nuclear proteins predicted (sensitivity) at or below given score [19].