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. 2013 Feb 25;8(2):e57662. doi: 10.1371/journal.pone.0057662

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© 2013 van Steenbeek et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Protein expression was measured for CCBL1, VCAM1 and WEE1 in liver tissue of healthy individuals (n = 4) and dogs affected with IHPSS (n = 4) and EHPSS (n = 4). ACTB was used as loading control and replacing primary antibody served as a negative control. CCBL1 was significantly down regulated in both IHPSS as well as EHPSS samples compared to the healthy controls (A). Expression of VCAM1 confirmed the findings of the immunohistochemistry with a downregulation in EHPSS samples was found compared to the IHPSS samples (B). WEE1 was found to be upregulated in IHPSS samples compared to healthy and EHPSS samples (C). The depicted bands are representative for the indicated groups.