Table 1. ACA reduced eosinophil numbers in bronchoalveolar lavage fluid recovered from mice with OVA-induced asthma.
NEUs | LYMs | EOSs | BASs | LUCs | |
(×106) | (×106) | (×106) | (×106) | (×106) | |
Vehicle control | 0.03±0.009 | 0.03±0.011 | 0.01±0.012 | 0.01±0.004 | 0.05±0.040 |
Albumin-induced asthma model | 0.04±0.012 | 0.11±0.052 a | 1.14±0.270 a | 0.01±0.004 | 0.10±0.023 |
Dexamethasone treatment | 0.02±0.005 | 0.03±0.010 b | 0.27±0.150 b | 0.01±0.002 | 0.08±0.034 |
25 mg/kg/day ACA treatment | 0.07±0.077 | 0.08±0.049 | 0.73±0.299 a,b,c | 0.01±0.023 | 0.13±0.059 a |
50 mg/kg/day ACA treatment | 0.02±0.007 | 0.04±0.019 b | 0.34±0.198 b,d | 0.01±0.004 | 0.07±0.019 |
Results are expressed as mean ± SD (n = 7). NEU, neutrophils; LYMs, lymphocytes; EOSs, eosinophils; BASs, basophils; LUCs, large unstained cells.
p<0.01 vs. CON (vehicle control); b p<0.01 vs. OVA (OVA-induced asthma model); c p<0.01 vs. DEX (dexamethasone treatment); d p<0.01 vs. ACA-25 mg (25 mg/kg/day ACA treatment).