Table 3. Average cells AP induced Ca2+ parameters in control (CON) and following introduction of H-89 (0.5 µmol/L; n = 6), *p<0.05 vs. drug control.
CON | W-7 | % Change | |
Peak Systolic Ca2+ (nmol/L) | 305±20 | 297±6* | −15±5* |
Minimum diastolic Ca2+ (nmol/L) | 118±20 | 127±4 | −3±4 |
Ca2+ amplitude (systolic-diastolic) (nmol/L) | 217±14 | 170±26* | −24±9* |
T-Pc (ms) | 80±13 | 82±11 | 5±9 |
T-50c (ms) | 157±27 | 191±16* | 12±6 |
T-90c (ms) | 282±22 | 344±15* | 13±4* |
Beats per min | 139±2 | 93±4* | −33±6* |