Table 2. Effect of NU6027 and Cisplatin in Chinese hamster ovary and human ovarian cancer cells.
Cell lines | NU6027 (µM;Ac) | Cisplatin (µM;Bc) | NU6027 (µM;Ae) | Cisplatin (µM;Be) | D | |
CHO | EM-C11 | 4 | 1.5 | 8 | 3 | 1 |
EM-C12 | 4 | 1.5 | 10 | 2.5 | 1 | |
OVCAR-3 | siRNA_1 | 6 | 1 | 10 | 2.5 | 1 |
siRNA_2 | 6 | 1 | 12 | 2 | 1 | |
SiRNA_3 | 6 | 1 | 10 | 3 | 0.93 | |
OVCAR-4 | siRNA_1 | 6 | 1 | 9 | 3 | 0.99 |
siRNA_2 | 6 | 1 | 10 | 2.5 | 1 | |
SiRNA_3 | 6 | 1 | 10 | 2.5 | 1 |
Ac and Bc, concentrations of drugs used in the combination treatment; Ae and Be concentrations of NU6027 alone and cisplatin alone respectively that produce a similar magnitude of effect; D (combination index.).