Table II.

Kinetic Parameters for in vitro Drug Release and Skin Permeation of the Finasteride-Loaded Liquid Crystalline Nanoparticles

Formulation code	In vitro drug release					In vitro skin permeation
	Zero-order kinetics (r 2)	First-order kinetics (r 2)	Higuchi kinetics (r 2)	Korsmeyer–Peppas kinetics		Zero-order kinetics (r 2)	Higuchi kinetics (r 2)	Korsmeyer–Peppas kinetics
				r 2	n			r 2	n
F1	0.960	0.968	0.992	0.994	0.80	nd	nd	nd	nd
F2	0.959	0.969	0.992	0.981	0.74	nd	nd	nd	nd
F3 (MO 9)	0.968	0.976	0.998	0.996	0.64	0.987	0.813	0.987	1.27
F4	0.928	0.939	0.985	0.977	0.72	nd	nd	nd	nd
F5	0.926	0.936	0.983	0.976	0.75	nd	nd	nd	nd
MO 1	0.968	0.977	0.993	0.987	0.83	0.984	0.835	0.853	1.19
MO 2	0.885	0.901	0.996	0.982	0.67	0.980	0.830	0.884	1.37
MO 4.5	0.958	0.935	0.998	0.996	0.99	0.985	0.843	0.680	1.33
GL 10	0.953	0.967	0.986	0.998	0.78	0.935	0.843	0.797	1.16
GL 20	0.947	0.957	0.981	0.976	0.83	0.935	0.843	0.792	1.15
OA 5	0.951	0.953	0.997	0.922	0.46	0.992	0.876	0.845	0.84
OA 10	0.862	0.864	0.983	0.952	0.55	0	0.883	0.810	0.99
PG 10	0.933	0.955	0.990	0.976	0.84	0.996	0.892	0.876	1.19
PG 20	0.873	0.895	0.993	0.966	0.95	0.969	0.806	0.880	1.25
PEG 7.5	0.966	0.959	0.999	0.996	0.69	0.986	0.842	0.882	1.30
PEG 15	0.961	0.982	0.998	0.979	0.79	0.979	0.865	0.831	1.44

Each value represents the mean (n = 3)

nd not determined, r ² correlation coefficient of linear regression, MO monoolein, P407 poloxamer 407, GL glycerol, OA oleic acid, PG propylene glycol, PEG polyethylene glycol 400