Table I.
List of Formulations Prepared by Varying Formulation and Process Parameters
| Formula | S1 | S2 | S3 | S4 | S5 |
|---|---|---|---|---|---|
| SSD concentration | 0.25% | 0.5% | 0.5% | 0.5% | 0.5% |
| Hydrophilic stabilizer concentration | Cremophor EL, 6% | Cremophor EL, 6% | Cremophor EL, 10% | Tween 80, 6% | Cremophor EL, 6% |
| Hydrophobic stabilizer concentration | Lauroglycol 90, 4% | Lauroglycol 90, 4% | Lauroglycol 90, 6% | Lauroglycol 90, 4% | Lauroglycol 90, 4% |
| Homogenization pressure cycles | 1,000 bars | 1,000 bars | 1,000 bars | 1,000 bars | 1,200 bars |
| Homogenization cycle numbers | 15 cycles | 30 cycles | 30 cycles | 30 cycles | 30 cycles |
SSD silver sulfadiazine