Table 2.
Group | Dose | n | Baseline | Peak | Post | p |
---|---|---|---|---|---|---|
Infrequent/nonsmokers | Placebo | 32 | 0.83±0.23 | 0.81±0.27 | 0.79±0.13 | N/A |
Low | 12 | 0.77±0.23 | 0.95±0.26 | 0.88±0.21 | 0.17 | |
Medium | 9 | 0.78±0.23 | 1.03±0.14 | 0.89±0.12 | 0.05 | |
High | 20 | 0.80±0.22 | 0.99±0.29 | 0.89±0.30 | 0.006 | |
smokers Frequent | Placebo | 10 | 0.91±0.25 | 0.90±0.18 | 0.88±0.22 | No main effects of dose or time or dose × time interaction |
Low | 4 | 0.65±0.14 | 0.78±0.17 | 0.75±0.23 | ||
Medium | 3 | 0.73±0.11 | 0.87±0.23 | 0.76±0.21 | ||
High | 5 | 0.84±0.14 | 0.94±0.12 | 0.98±0.17 |
Ratio of estimated time to true time derived from a linear mixed model that included and random subject effects as well as dose and time as within-subjects effects. P-values are for comparison between dose and placebo.