Table 2.

Time Estimation Ratio of estimated time to true time

Group	Dose	n	Baseline	Peak	Post	p
Infrequent/nonsmokers	Placebo	32	0.83±0.23	0.81±0.27	0.79±0.13	N/A
	Low	12	0.77±0.23	0.95±0.26	0.88±0.21	0.17
	Medium	9	0.78±0.23	1.03±0.14	0.89±0.12	0.05
	High	20	0.80±0.22	0.99±0.29	0.89±0.30	0.006
smokers Frequent	Placebo	10	0.91±0.25	0.90±0.18	0.88±0.22	No main effects of dose or time or dose × time interaction
	Low	4	0.65±0.14	0.78±0.17	0.75±0.23
	Medium	3	0.73±0.11	0.87±0.23	0.76±0.21
	High	5	0.84±0.14	0.94±0.12	0.98±0.17

Ratio of estimated time to true time derived from a linear mixed model that included and random subject effects as well as dose and time as within-subjects effects. P-values are for comparison between dose and placebo.