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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Genes Brain Behav. 2012 Nov 27;12(2):241–249. doi: 10.1111/j.1601-183X.2012.00867.x

Figure 3.

Figure 3

GIR knock out (−/−) mice are resilient to stress evoked anxiety. Open field testing for time spent in center of center area (a), border (b) and motor activity during the total test period (c) for wild type (+/+) and GIR knock out (−/−) mice. A highly significant anxiogenic effect of restraint was observed as decreased center time (a) and increased border time (b) only in the wild-type mice but was absent in GIR −/− mice, (* p<0.05 versus other conditions). There was no genotype difference at baseline. Motor activity showed no significant differences between genotypes at baseline. GIR −/− mice showed increased activity post stress as compared to +/+ mice (p<0.05); Data are mean ± SEM; n= 8–9/group.