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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Integr Biol (Camb). 2013 Mar;5(3):510–522. doi: 10.1039/c2ib20090b

Fig 4.

Fig 4

Conceptual model of angiogenic population. (a) Uniform population model posits that endothelial population is homogeneous in state transition dynamics and the population is unimodally distributed in transition rate parameter space. Under control condition, the population assumes a unimodal distribution in state transition rate parameters (top). Treatments with cytokines (shown as black arrows) cause individual cells to respond in a similar manner and the population distribution to shift unidirectionally (bottom left and right shown as results of two different stimulations). (b) Diverse population model posits that endothelial population is heterogeneous in state transition dynamics. Under control condition, the population consists of multiple subpopulations characterized by different transition rate parameters (top). Treatments with cytokines cause changes in the fractions of cell within subpopulations without shifting subpopulations centers (bottom left and right).