TABLE 1.

Clinical Characteristics of 10 Patients Whose Initial NMO Spectrum Disorder Symptom Was Intractable Vomiting (with Nausea)

Case	Sex/age at vomiting onset	Subspecialty consultations/ GI evaluation	Duration of vomiting (days)	Associated symptoms	No. vomiting episodes per day	Vomiting periodicity (cyclic vs non-cyclic)	Provisional diagnosis	Interval from vomiting onset to ON or LETUM (weeks)	AQP4-IgG titer *	Diagnosis at last follow-up	Duration of follow-up from vomiting onset (months)
1	F/41	Gastroenterology, Internal Medicine, Cardiology, Rheumatology, Gynecology; gastroscopy with biopsy, small bowel X-ray, abdominal ultrasound, abdomen and pelvis CT, wireless capsule endoscopy	90	Hiccups	15	Non-cyclic	Viral illness	12	30720	NMO	11
2	F/40	Gastroenterology; gastroscopy, small bowel X-ray, liver ultrasound, abdomen CT, cholecystectomy	90	None	N/A	Non-cyclic	Gallbladder polyp	20	240	rLETM	84
3	F/50	Neurology; none	7	Limb ataxia	N/A	Non-cyclic	Multiple sclerosis	0	30720	NMO	31
4	F/43	Gastroenterology; abdomen ultrasound, gastroscopy with biopsy, small bowel X-ray	7	Hiccups	N/A	Non-cyclic	None	18	7680	NMO	60
5	F/26	Gastroenterology; gastroscopy with biopsy, abdomen ultrasound, small bowel X-ray	28	Hiccups	N/A	Non-cyclic	Viral illness	260	960	NMO	84
6	F/45	None; none	1	None	N/A	Non-cyclic	None	20	15360	NMO	12
7	F/41	Gastroenterology; gastroscopy, abdomen ultrasound, small bowel X-ray None; none	21	None	N/A	Non-cyclic	None	720	1920	NMO	180
8	F/51		4	None	N/A	Non-cyclic	Viral illness	1	7680	NMO	36
9	M/60	Gastroenterology; gastroscopy with biopsy, small bowel X-ray, abdomen ultrasound	15	Hiccups	14	Non-cyclic	None	2	CSF only positive	NMO	42
10	F/72	Internal Medicine	3	None	20	Non-cyclic	Viral illness	64	960	rLETM	26

^*Ascertained by tissue-based immunofluorescence testing of serum.

CT, computed tomography; F, female; M, male; ON, optic neuritis; CSF, cerebrospinal fluid; rLETM, relapsing longitudinally-extensive transverse myelitis; N/A, information not available;

NMO, neuromyelitis optica.