Table 4. List of top-ranked genes in terms of survival concordance index of the METABRIC discovery dataset demonstrating enrichment of the mitotic CIN attractor.
Rank | Gene Symbol | Concordance Index | Rank | Gene Symbol | Concordance Index |
1 | CDCA5 | 0.670 | 51 | PRR11 | 0.639 |
2 | AURKA | 0.663 | 52 | LOC651816 | 0.638 |
3 | KIF20A | 0.662 | 53 | KRT80 | 0.638 |
4 | TROAP | 0.661 | 54 | C15orf42 | 0.637 |
5 | UBE2C | 0.659 | 55 | SGOL1 | 0.637 |
6 | AURKA | 0.658 | 56 | GPI | 0.637 |
7 | FAM83D | 0.657 | 57 | CEP55 | 0.637 |
8 | SHMT2 | 0.655 | 58 | MCM10 | 0.636 |
9 | UBE2C | 0.655 | 59 | PKMYT1 | 0.635 |
10 | CCNB2 | 0.653 | 60 | CENPN | 0.635 |
11 | TPX2 | 0.653 | 61 | C20orf24 | 0.635 |
12 | EXO1 | 0.653 | 62 | SPC24 | 0.635 |
13 | ORC6 | 0.653 | 63 | RIPK4 | 0.635 |
14 | CENPA | 0.653 | 64 | TOMM40 | 0.634 |
15 | C1orf106 | 0.652 | 65 | ANLN | 0.634 |
16 | GTSE1 | 0.652 | 66 | ADRM1 | 0.634 |
17 | MELK | 0.651 | 67 | NCAPG | 0.633 |
18 | STIP1 | 0.651 | 68 | CDCA8 | 0.633 |
19 | SPC25 | 0.649 | 69 | AIF1L | 0.633 |
20 | CENPA | 0.649 | 70 | MRPS5 | 0.633 |
21 | GARS | 0.649 | 71 | GPR56 | 0.633 |
22 | MELK | 0.649 | 72 | PEX13 | 0.633 |
23 | UCK2 | 0.648 | 73 | ENO1 | 0.633 |
24 | HJURP | 0.648 | 74 | NUTF2 | 0.633 |
25 | PTTG1 | 0.647 | 75 | MEMO1 | 0.632 |
26 | CBX2 | 0.646 | 76 | TXNRD1 | 0.632 |
27 | CCNE1 | 0.646 | 77 | SLC7A5 | 0.631 |
28 | PLK1 | 0.646 | 78 | FOXM1 | 0.631 |
29 | KIF2C | 0.645 | 79 | KIF14 | 0.631 |
30 | CCNA2 | 0.645 | 80 | PPP1R14B | 0.631 |
31 | GMPSP1 | 0.645 | 81 | FAM54A | 0.630 |
32 | AURKB | 0.645 | 82 | C20orf24 | 0.630 |
33 | BUB1 | 0.644 | 83 | SGOL1 | 0.630 |
34 | TRIP13 | 0.643 | 84 | NUP93 | 0.630 |
35 | FOXM1 | 0.643 | 85 | ZNF695 | 0.630 |
36 | CDC20 | 0.643 | 86 | BIRC5 | 0.630 |
37 | LOC731049 | 0.642 | 87 | CENPL | 0.630 |
38 | POLQ | 0.642 | 88 | SOX11 | 0.630 |
39 | GSK3B | 0.642 | 89 | KIF23 | 0.629 |
40 | CCNE1 | 0.642 | 90 | SLC52A2 | 0.629 |
41 | KIF4A | 0.641 | 91 | AIF1L | 0.629 |
42 | PRC1 | 0.641 | 92 | FEN1 | 0.629 |
43 | LAD1 | 0.641 | 93 | CDC25A | 0.629 |
44 | FAM64A | 0.641 | 94 | CDCA3 | 0.628 |
45 | SAPCD2 | 0.641 | 95 | TMEM132A | 0.628 |
46 | RACGAP1 | 0.641 | 96 | CENPE | 0.628 |
47 | POLR2D | 0.641 | 97 | NACC2 | 0.628 |
48 | CKAP2L | 0.640 | 98 | TTK | 0.628 |
49 | PTTG1 | 0.640 | 99 | SNRPA1 | 0.628 |
50 | ECE2 | 0.639 | 100 | MMP15 | 0.628 |
The 47 underlined genes are also among the top 100 genes of the mitotic CIN attractor (Table 2).