Table 3.

Regulated genes in the functional categories and canonical pathways at 72 h post-TBI.

Functional pathways
Cell-to-cell signaling and interaction	Cacna1g, Kcnh1, Scn2a, Sv2b, Egr3, Cacnb4, Rgs4, Cck, Stx1a, Hrh3, Efna5, Sst, Htr1f, Ptgs2, Chrna5, Adra1b, Gabra3, Mmp9, Agt, Htr2a
Molecular transport	Cacna1g, Kcnh1, Clic5, Scn2a, Slc4a11, Cacnb4, Rgs4, Kcnip3, Cck, Stx1a, Hrh3, Kcnh7, Sst, Lyve1, Ptgs2, Chrna5, Gabre, Adra1b, Kcng3, Atp2b4, Agt, Htr2a
small molecular biochemistry	Kcnh1, Rxfp2, Cacnb4, Sstr1, Rgs4, Kcnip3, Cck, Stx1a, Pde1a, Hrh3, Acaa2, Ephb6, Gpx3, Tph1, Sst, Ptgs2, Lyve1, Chrna5, Atp2b4, Adra1b, Htr2a, Agt
Organismal injury and abnormalities	Cacna1l, Cacna1g, Kcnip3, Htr1f, Ptgs2, Chrna5, Gabre, Adra1b, Mmp9, Gabra3, Agt, Htr2a
Cell signaling	Cacna1g, Rxfp2, Cacnb4, Rgs4, Sstr1, Kcnip3, Cck, Ped1a, Hrh3, Gnat2, Sst, Htr1f, Ptgs2, Adra1b, Atp2b4, Htr2a, Agt
Drug metabolism	Sst, Rgs4, Lyve1, Cck, Ptgs2, Chrna5, Stx1a, Hrh3, Adra1b, Agt, Htr2a
Cell morphology	Efna5, Sst, Rgs4, Ptgs2, Adra1b, Mmp9, Agt
Cellular movement	Satb2, Sst, Rgs4, Tbr1, Ptgs2, Mmp9, Agt
DNA replication, recombination, and repair	Sst, Ptgs2, Ped1a, Agt
Nucleic acid metabolism	Ephb6, Rxfp2, Cacnb4, Sstr1, Sst, Cck, Ptgs2, Ped1a, Hrh3, Acaa2, Atp2b4, Agt
Canonical pathway
G-protein couple receptor signaling	Rxfp2, Rgs4, Sstr1, Htr1f, Tacr3, Pde1a, Hrh3, Adra1b, Htr2a
Cholecystokinin/gastrin-mediated signaling	Sst, Mef2c, Cck, Ptgs2
Serotonin receptor signaling	Tph1, Htr2a
LXR/RXR activation	Ptgs2, Mmp9, Agt
Gα12/13 signaling	Cdh7, Cdh12, Mef2c
Cytotoxic T lymphocyte-mediated apoptosis of target cells	Hla-Dq1a, RT1-M6-1/Rt1-M6-2
GABA receptor signaling	Gabre, Gabra3
c-AMP-mediated signaling	Rgs4, Htr1f, Pde1a, Hrh3
OX40 signaling pathway	Hla-Dq1a, RT1-M6-1/Rt1-MG-2
AMPK signaling	Pfkp, Chrna5, Adra1b