Table 2.

Estimated probability of clinical milestones

	From symptom onset to baseline visit		During first year of follow-up		During second year of follow-up
	Number of events/patients at risk	Estimated probability (95% CI) of an event*	Number of events/patients at risk	Estimated probability (95% CI) of an event*	Number of events/patients at risk	Estimated probability (95% CI) of an event*
Falls at least once a day	34/105	23% (13·3– 40·0%)†	11/42	21% (10·7–40·2%)†	8/16	45% (20·4–98·4%)‡
Feeding by nasogastric tube or gastrostomy	3/83	3% (0·7–12·9%)†	7/51	13% (4·5–38·0%)§	2/29	6% (1·4–30·0%)¶
Unintelligible speech	12/117	7% (3·2–15·9%)†	11/59	13% (6·0–28·7%)†	5/26	15% (5·3–39·9%)§
Wheelchair dependency	17/123	9% (4·3–18·4%)†	11/59	13% (6·3–28·3%)†	5/25	14% (5·2–37·9%)‖

^*Estimated probabilities of an event fitted by an interval-censored survival model applying a complementary log-log link function. p values are Wald-χ².

^†p<0·0001.

^‡p=0·046.

^§p=0·0002.

^¶p=0·0005.

^‖p=0·0001.