TABLE 4.
Adipose Tissue-Derived Mediator Profile by Uremia and Adipose Depots
| Mediator (pg/mg) | Sensitivity Analysis (Extremity Adipose Tissue)
|
P value | Sensitivity analysis (Extremity vs Breast Adipose Tissue in Non-uremic Patients)
|
P value | ||
|---|---|---|---|---|---|---|
| Uremia (n=17) | Non-uremia (n=46) | Extremity Fat (n=46) | Breast Fat (n=8) | |||
| IL-6 | 2.1 (0–11.1) | 2.6 (0–7.4) | 0.99 | 2.6 (0–7.4) | 2.0 (1.5–2.6) | 0.76 |
| IL-8 | 2.0 (0.7–2.4) | 1.9 (1.2–2.7) | 0.68 | 1.9 (1.2–2.7) | 2.4 (2.1–2.7) | 0.26 |
| Leptin | 155 (47–515) | 1,372 (406–4,054) | <0.001 | 1,372 (406–4,054) | 1,635 (1,221–2,301) | 0.69 |
| TNF-alpha | 0.4 (0.3–0.8) | 0.6 (0.4–0.9) | 0.17 | 0.6 (0.4–0.9) | 0.8 (0.4–1.0) | 0.74 |
| MCP-1 | 26.4 (12.3–100.2) | 65.7 (36.8–158.0) | 0.06 | 65.7 (36.8–158.0) | 30.6 (17.8–37.0) | 0.01 |
| Adiponectin | 137,001(85,019–272,364) | 329,345 (240,588–471,108) | <0.001 | 329,345 (240,588–471,108) | 412,001 (296,999–610,579) | 0.29 |
| Resistin | 2,563 (2,055–3,448) | 809 (531–1,797) | <0.001 | 809 (531–1,797) | 1,639 (1,051–2,265) | 0.04 |
| PAI-1 | 100.5 (61.4–149.4) | 99.3 (50.2–149.1) | 0.87 | 99.3 (50.2–149.1) | 94.0 (75.8–243.1) | 0.72 |