Table 5.

Compared levels of bone turnover markers in AN patients and healthy matched population.

Bone turnover markers*	AN/CT	Reference
Blood OC	(→)↓1	Calero et al. (1999), Grinspoon et al. (1999), Caillot-Augusseau et al. (2000), Gordon et al. (2002), Misra et al. (2003, 2004b, 2006, 2007, 2008), Weinbrenner et al. (2003), Galusca et al. (2006), Legroux-Gérot et al. (2007), Ohwada et al. (2007), Viapiana et al. (2007), Estour et al. (2010), Ostrowska et al. (2010, 2012a,b)
Blood procollagen type 1 N-terminal propeptide (PINP)	→↓	Calero et al. (1999), Faje et al. (2012)
Blood procollagen type 1 C-terminal propeptide (PICP)	↓	Misra et al. (2003, 2004b, 2006, 2007), Heer et al. (2004), Mika et al. (2007)
Blood bone specific alkaline phosphatase (BSAP)	(→)↓2	Calero et al. (1999), Gordon et al. (2002), Misra et al. (2003, 2006), Heer et al. (2004), Bolton et al. (2005), Galusca et al. (2006), Legroux-Gérot et al. (2007), Mika et al. (2007), Ohwada et al. (2007), Viapiana et al. (2007)
Blood or urinary c-terminal cross-linking telopeptide of type 1 collagen (CTX)	↑↓3	Caillot-Augusseau et al. (2000), Weinbrenner et al. (2003), Galusca et al. (2006), Mika et al. (2007), Estour et al. (2010), Ostrowska et al. (2010, 2012a,b), Faje et al. (2012)
Blood cross-linked N-telopeptides of type 1 collagen (NTX)	↑↓	Gordon et al. (2002), Dominguez et al. (2007)
Urinary NTX/creatinine	↑↓4	Grinspoon et al. (1999), Misra et al. (2003, 2006, 2007, 2008), Dominguez et al. (2007)

¹All but three studies found significant or non-significant decreased OC levels.

²All but three studies found significant or non-significant decreased BSAP levels

³Increased CTX found by Caillot-Augusseau et al. (2000), Weinbrenner et al. (2003), Galusca et al. (2006), Ohwada et al. (2007), and Estour et al. (2010).

⁴Only Grinspoon found increased urinary NTX/creatinine levels.

*Bone resorption markers are on gray background.