Figure 3.

Effects of radiation, cetuximab, and cisplatin in three tumorgrafts: UW-SCC6 (A), UW-SCC14N (B), and UW-SCC22 (C). Treatments, started when subcutaneously growing tumors reached a volume of approximately 200 mm³, were administered twice weekly for two weeks as described in the methods. Growth curves plotting the mean (+/− SEM) tumor volume over time are shown. For each group, n=8–10 mice with dual tumors began treatment. ^*p<0.01, ^#p=not significant. D) Early passage cell strains developed from UW-SCC24 and UW-SCC14N were assessed for proliferative potential in the presence of indicated drugs. Cell number was estimated by CCK8 assay and standardized to the maximum relative value of vehicle control.