Fig. 4.

Clustering analysis of T3 responsive genes. Heat map (Center) and average behavior of the 10 different clusters of genes obtained after k-means clustering analysis are shown. Blue, low levels of expression; yellow, high levels of expression (normalized and mean-centered values). C17.2α cells are on the left and C17.2β cells on the right. For each cell line, untreated cells (−T3) are on the left and treated cells (+T3) on the right, each category being subdivided into three different columns corresponding to the duration of treatment (6, 12, or 24 h). Each cluster is numbered (K1–K10). Graphs represent the mean value of gene expression ±SD for each cluster at different time points. C17.2α are on the left and C17.2β on the right. Blue line, untreated cells; red line, T3-treated cells.