Fig. 7.

Diagrammatic representation of some of the cell–cell communication elements and interaction networks perturbed in sorted sandwich cultures. N, neurons (upper one-half of the figure); G, glia (lower one-half of the figure). Representative changes in neuronal and glial cell surface molecules as well as their linked intracellular signaling components are shown. Down-regulated genes are indicated by blue boxes, whereas up-regulated genes are shown as red boxes. Both cell autonomous (lower one-half of the box representing a gene) and nonautonomous changes (upper one-half of the box representing a gene) in neurons are shown.