Fig. 1.
Mad2 deficiency provokes hair loss in mouse epidermis. (A) Macroscopic phenotype of Mad2 conditional KO (cKO) mice in neonates and adults. (B) Quantitative PCR comparing Mad2 RNA levels in Mad2f/f, Krt14-Cre+ (Mad2-deficient), and control epidermis in neonates and adults. Error bars indicate SE of the mean (SEM) of at least two biological replicates. (C) Western blot for Mad2 in Mad2-deficient and control epidermis. (D) Kaplan-Meier curve depicting survival of Mad2-deficient mice within the first year.