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. 2013 Feb 4;110(8):2928–2933. doi: 10.1073/pnas.1217388110

Fig. 2.

Fig. 2.

Krt14-Cre; Mad2 conditional mice display dramatic aneuploidy in the epidermis. (A) DNA content distribution in control and Mad2-deficient epidermal cells in neonates and adults. The CV is used as a measure of the variance of DNA content within the G1 peak. (B) Interphase FISH for chromosomes 15 (red) and 19 (green) on freshly isolated control and Mad2-deficient keratinocytes. (C) Percentage of cells showing more than two copies of chromosome 15 or 19 assessed by interphase FISH (aneuploidy index) in Mad2-deficient or control epidermis. Error bars indicate SE of the mean (SEM) values for at least three biological replicates. Individual values can be found in Table S1.