. 2013 Feb 4;110(8):E726–E735. doi: 10.1073/pnas.1300424110

Table 1.

Synaptic proteins significantly reduced in sensory-deprived barrel cortex

Protein	T/B (%)	P	Average ¹⁴N/¹⁵N pairs	Up/down-regulation at the synapse	IPI
Membrane-bound
Fry	30	0.026	2	(25)^*	IPI00655161.6
KChIP4	54	0.003	2	(26)^†	IPI00621710.2
LPPR4	57	0.013	10	(27)^†^,^‡	IPI00420590.3
GluA1	57	0.035	15	(28)^†^,^‡	IPI00407939.1
Slc4a7	62	0.009	7	(29)^‡	IPI00664442.3
GluN1	63	0.013	14	(30)^†^,^§	IPI00755015.1
TARP-γ3	67	0.036	5	(31)^†	IPI00122300.1
LPPR2	67	0.048	4		IPI00222105.1
Pcdh1	68	0.014	13		IPI00719927.2
GIRK1	68	0.032	4	(32)^‡	IPI00119615.1
Teneurin-2	69	0.018	9	(33)^§	IPI00123782.6
Robo1	69	0.049	2	(34)^*	IPI00130664.5
Icam5	69	0.015	13	(35)^§	IPI00877299.1
GIRK2	70	0.015	3	(32)^‡	IPI00227086.2
Gprin1	70	0.028	25	(36)^*	IPI00138232.4
GluA2	70	0.049	28	(37)^†^,^‡^,^§	IPI00608015.1
Cpne6	70	0.041	14		IPI00927968.1
GluN2B	70	0.028	27	(38)^†^,^‡	IPI00321320.3
Flotillin-2	74	0.024	6		IPI00754549.1
Dpp6	75	0.014	20	(39)^†	IPI00880742.1
Cacn-β1	75	0.001	5	(40)^†	IPI00321850.3
Gng2	76	0.026	6		IPI00230194.5
Rab35	76	0.027	5	(41)^*	IPI00130489.1
GABAA-α2	77	0.034	5	(42)^*	IPI00110598.1
GluN2A	78	0.012	21	(43)^†	IPI00118380.2
Plexin-A1	78	0.041	18	(44)^*	IPI00137311.1
Gnaq	78	0.009	16	(45)^‡	IPI00228618.5
Flotillin-1	79	0.021	10	(46)^*^,^†^,^§	IPI00117181.1
Slc8a2	79	0.044	20	(47)^†^,^‡	IPI00170310.1
Lphn 3	79	0.040	6	(48)^‡^,^§	IPI00619988.3
Camk-v	79	0.012	18		IPI00122486.3
KCNN2	81	0.026	2	(49)^†^,^‡	IPI00467814.2
Adcy9	82	0.001	12		IPI00313750.3
Slc6a7	82	0.044	3		IPI00420909.1
ECM
Tnc	43	0.005	7	(50)^†^,^‡	IPI00403938.2
Annexin-2	68	0.033	1	(51)^*	IPI00468203.3
Glypican1	75	0.012	8		IPI00137336.1
Hapln4	78	0.015	4		IPI00229184.3
Intracellular
Rgs12	47	0.007	1	(52)^*	IPI00229481.2
Bad	62	0.007	1	(53)^†	IPI00119986.1
GKAP	66	0.011	7	(54)^§	IPI00136402.2
Prickle2	68	0.016	7	(55)^*	IPI00349970.6
Ptk2b	72	0.023	10	(56)^†	IPI00133132.1
Kalirin	73	0.009	18	(57)^*^,^†^,^‡^,^§	IPI00848608.1
Map4	73	0.028	15		IPI00406741.5
Shank1	73	0.047	20	(58)^†^,^‡^,^§	IPI00758339.1
SynGAP1	75	0.028	53	(59)^†^,^‡^,^§	IPI00663736.2
Catenin-α2	76	0.024	30	(60)^*^,^‡^,^§	IPI00119870.2
PKCγ	76	0.007	24	(61)^†^,^‡	IPI00122069.1
Translin	77	0.044	3	(62)^‡	IPI00124684.1
Rgs14	77	0.005	4	(63)^†^,^‡	IPI00125649.1
Sap102	80	0.021	30	(64, 65)^†^,^‡^,^§	IPI00623890.1
Catenin-β1	81	0.016	26	(60)^*^,^†^,^‡^,^§	IPI00125899.1
Catenin-δ2	81	0.042	17	(60)^*^,^†^,^‡^,^§	IPI00136135.1
Map2	81	0.003	55		IPI00118075.1
Arp2	83	0.021	12	(66)^*	IPI00177038.1

Proteins are grouped by subsynaptic location with their corresponding IPI number. The ratio of average trimmed:brushed protein levels (T/B), number of quantified peptides (¹⁴N/¹⁵N pairs) from which the average was calculated, and ANOVA P value for each protein are indicated. Light gray fill indicates proteins altered by more than 1.5-fold. Dark gray fill indicates proteins altered by more than 2.0-fold.

*Study demonstrates the effects of down-regulation or up-regulation of protein on neurite morphology.

^†Study demonstrates the effects of down-regulation or up-regulation of protein on synaptic transmission.

^‡Study demonstrates the effects of down-regulation or up-regulation of protein on behavior.

^§Study demonstrates the effects of down-regulation or up-regulation of protein on spine morphology.