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Cefuroxime enhances the pathogenicity of the BP10 line. The weakly encephalitogenic BP10 line was stimulated for 3 d with MBP in the presence or absence of cefuroxime (50 μg/mL). The stimulated T cells were then inoculated (107 per rat) i.p. to naïve rats, and EAE was scored. The recipients of the cefuroxime-treated cells showed significantly more severe disease scores; asterisks indicate significant (P < 0.05) changes between cefuroxime and control group.
